Enzymatic inactivation of antibiotics occurs with several of the natural product antibiotic classes but has not yet been observed as a major route of resistance development for the classes of synthetic antibacterials the sulfamethoxazole trimethoprim combination the fluoroquinolones or the oxazolidinones the most widespread mode of clinical resistance development to lactam antibiotics is the expression of lactamases that hydrolyze the antibiotic two approaches have been taken in . Book antibiotics actions origins resistance 2003 ppx 335 pp refmany abstract this book provides a comprehensive up to date account of those structural classes of antibiotics antibiotics subject category chemicals and chemical groups. Reviewed by john mann for reproduction of material from njc reproduced from ref xx with permission from the centre national de la recherche scientifique cnrs and the royal society of chemistry. Antibiotics actions origins resistance antibiotics christopher walsh asm press 2003 medical 335 pages 0 reviews a comprehensive account of the structural classes of antibiotics that
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